{"id":116,"date":"2019-09-18T20:04:58","date_gmt":"2019-09-19T00:04:58","guid":{"rendered":"https:\/\/people.bsu.edu\/wqshi\/?page_id=116"},"modified":"2026-04-24T22:22:58","modified_gmt":"2026-04-25T02:22:58","slug":"publications","status":"publish","type":"page","link":"https:\/\/people.bsu.edu\/wqshi\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

\"Google<\/a><\/p>\n

(Corresponding author denoted by *; Undergraduate denoted by \u00a7<\/sup>)<\/strong><\/p>\n

Independent:<\/span><\/h2>\n

20. Hall, B. S.; Owusu-Boateng, K.; McPhail, K. L.; Shi, W. Q.<\/strong>; Simmonds, R. E.* \u201cA mycobacterial Sec61 inhibitor disrupts lysosome function by blocking Vacuolar-ATPase biosynthesis\u201d, Eur. J. Cell Biol.<\/span><\/em> 2026<\/strong>, 151541. (open access<\/a>)<\/p>\n

19. Sicairos, B.; Zhou, J.; Hu, Z.; Zhang, Q.;*\u00a0 Shi, W. Q.<\/strong>;* Du, Y.* \u201cEffect of Ipomoeassin F on the Synthesis of Membrane and Secretory Proteins in Triple-Negative Breast Cancer Cells\u201d, ACS Omega<\/em> 2025<\/strong>, 10<\/em>, 38522\u201338530<\/span>. (open access<\/a>)<\/p>\n

18.\u00a0 Khosravi, A.; Nnamdi, P.; May, A.; Slattery, K.\u00a7<\/sup>; Sammelson, R. E.; Shi, W. Q.<\/strong>* “Structural Modifications Reveal Dual Functions of the C-4 Carbonyl Group in the Fatty Acid Chain of Ipomoeassin F”, Molecules<\/em> 2025<\/strong>, 30<\/em>, 400. (open access<\/a>)\"\"<\/a><\/p>\n

17.\u00a0 Tao, S.; Yang, E. J.; Zong, G.; Mou, P. K.; Ren, G.; Pu, Y.; Chen, L.; Kwon, H. J.; Zhou, J.; Hu, Z.; Khosravi, A.; Zhang, Q.; Du, Y.;*, Shi, W. Q.<\/strong>;* Shim, J. S.* \u201cER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones\u201d, Int. J. Biol. Sci.<\/em> 2023<\/strong>, 19<\/em>, 4020\u20134035. (open access<\/a>)<\/p>\n

16.\u00a0 Hsieh, L. T.-H.; Hall, B. S.; Newcombe, J.; Mendum, T. A.; Umrania, Y.; Deery, M. J.; Shi, W. Q.<\/strong>; Salguero, F. J.; Simmonds, R. E.* \u201cMycolactone causes catastrophic Sec61-dependent loss of the endothelial glycocalyx and basement membrane: a new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans<\/em> infection\u201d eLife<\/em>, 2023<\/strong>, 12:RP86931. (open access<\/a>)<\/p>\n

15.\u00a0 Itskanov, S.; Wang, L.; Junne, T.; Sheriff, R.; Xiao, L.; Blanchard, N.; Shi, W. Q.<\/strong>; Forsyth, C.; Hoepfner, D.; Spiess, M.; Park, E.* \u201cA common mechanism of Sec61 translocon inhibition by small molecules\u201d Nat. Chem. Biol.<\/em> 2023<\/strong>, 19, 1063\u20131071. (https:\/\/doi.org\/10.1038\/s41589-023-01337-y<\/a>) (open access<\/a>)<\/p>\n

14.\u00a0 O\u2019Keefe, S.*,<\/sup>\u2020<\/sup>; Bhadra, P.\u2020<\/sup>; Duah, K. B.\u2020<\/sup>; Zong, G.\u2020<\/sup>; Tenay, L.; Andrews, L. E.\u00a7<\/sup>; Schneider, H.\u00a7<\/sup>; Anderson, A.\u00a7<\/sup>; Hu, Z.; Aljewari, H. S.; Hall, B. S.; Simmonds, R. E.; Helms, V.*; High, S*; Shi, W. Q.<\/strong>* \u201cSynthesis, biological evaluation and docking studies of ring-opened analogues of ipomoeassin F\u201d, Molecules<\/em> 2022<\/strong>, 27<\/em>, 4419. (\u2020<\/sup> Equal contribution) (open access<\/a>)<\/p>\n

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13.\u00a0 Leznicki, P.;* Schneider, H.\u00a7<\/sup>; Harvey, J.\u00a7<\/sup>; Shi, W. Q.<\/strong>; High, S.* \u201cCo-translational biogenesis of lipid droplet integral membrane proteins\u201d, J. Cell Sci<\/em>. 2022<\/strong><\/span>, 135<\/em>, jcs259220. (open access<\/a>)<\/p>\n

12.\u00a0 O\u2019Keefe, S.; Zong, G.; Duah, K. B.; Andrews, L. E.\u00a7<\/sup>; Shi, W. Q.<\/strong>; High, S.* \u201c<\/strong>An alternative pathway for membrane protein biogenesis at the endoplasmic reticulum\u201d, <\/strong>Commun. Biol.<\/em> 2021<\/strong><\/span>, 4<\/em>, 828. (open access<\/a>)<\/p>\n

11.\u00a0\u00a0 Roboti, P.; O\u2019Keefe, S.; Duah, K. B.; Shi, W. Q.<\/strong>; High, S.* \u201cIpomoessin-F disrupts multiple aspects of secretory protein biogenesis\u201d, Sci. Rep.<\/em> 2021<\/strong><\/span>, 11<\/em>, 11562. (open access<\/a>)<\/p>\n

10.\u00a0\u00a0 O\u2019Keefe, S.; Roboti, P.; Duah, K. B.; Zong, G.; Schneider, H.\u00a7<\/sup>; Shi, W. Q.<\/strong>; High, S.* \u201cIpomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor\u201d, J. Cell Sci<\/em>. 2021<\/strong><\/span>, 134<\/em>, jcs257758. (open access<\/a>)<\/p>\n

9.\u00a0\u00a0\u00a0\u00a0 Zong, G.; Hu, Z.; Duah, K. B.; Andrews, L. E.\u00a7<\/sup>; Zhou, J.; O\u2019Keefe, S.; Whisenhunt, L.; Shim, J. S.; Du, Y.; High, S.; Shi, W. Q.*<\/strong> \u201cRing-expansion leads to a more potent analogue of ipomoeassin F\u201d, J. Org. Chem.<\/em>\u00a02020<\/strong>, 85<\/span><\/em>, 16226\u201316235<\/span>. (open access<\/a>)<\/p>\n

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8.\u00a0\u00a0\u00a0\u00a0 Steinberg, R.; Origi, A.; Natriashvili, A.; Sarmah, P.; Licheva, M.; Walker, P. M.\u00a7<\/sup>; Kraft, C.; High, S.; Luirink, J.; Shi, W. Q.<\/strong>; Helmst\u00e4dter, M.; Ulbrich, M. H.; and Koch, H.-G.* \u201cPost-translational insertion of small membrane proteins by the bacterial signal recognition particle\u201d, PLoS Biol.<\/em> published September 30, 2020<\/strong><\/span>. (open access<\/a>)<\/p>\n

7.\u00a0\u00a0\u00a0\u00a0\u00a0 Zong, G.\u2020<\/sup>; Hu, Z.\u2020<\/sup>; O’Keefe, S.;#<\/sup> Tranter, D.;#<\/sup> Iannotti, M. J.;#<\/sup> Baron, L.;#<\/sup> Hall, B.;# <\/sup>Corfield, K.;#<\/sup> Paatero, A.; Henderson, M. J.;#<\/sup> Roboti, P.;#<\/sup> Zhou, J.; Sun, X.; Govindarajan, M.; Rohde, J.; Blanchard, N.; Simmonds, R.;* Inglese, J.;* Du, Y.;*\u00a0Demangel, C.;* High, S.;* Paavilainen, V. O.;* Shi, W. Q.<\/strong>* \u201cIpomoeassin F binds Sec61\u03b1 to inhibit protein translocation\u201d, J. Am. Chem. Soc. <\/em>2019<\/strong>, 141<\/em>, 8450\u20138461. <\/strong>(\u2020, <\/sup># <\/sup>Equal contribution) (open access<\/a>)<\/p>\n

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6.\u00a0\u00a0\u00a0\u00a0\u00a0 Kearney, S. E.; Zahora\u0301nszky-Ko\u030bhalmi, G.; Brimacombe, K. R.; Henderson, M. J.; Lynch, C.; Zhao, T.; \u2026 Shi, W.<\/strong>; \u2026 Hall, M. D.;* Xia, M.; Guha, R.; Rohde, J. M.* \u201cCanvass: A Crowd-Sourced, Natural Product Screening Library for Exploring Biological Space\u201d, ACS Cent. Sci. <\/em>2018<\/strong>, 4<\/em>, 1727\u20131741. (open access<\/a>)<\/p>\n

5.\u00a0\u00a0 \u00a0\u00a0 Zong, G.; Sun, X.; Bhakta, R.\u00a7<\/sup>; Whisenhunt, L.; Hu, Z.; Wang, F.; Shi, W. Q.<\/strong>* \u201cNew insights into structure\u2013activity relationship of ipomoeassin F from its bioisosteric 5-oxa\/aza analogues\u201d, <\/strong>Eur. J. Med. Chem.<\/em> 2018<\/strong>, 144<\/em>, 751\u2013757. (open access<\/a>)
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4.\u00a0\u00a0\u00a0\u00a0\u00a0 Zong, G.\u2020<\/sup>; Hirsch, M.\u2020<\/sup>; Mondrik, C.\u00a7<\/sup>; Hu, Z.; Shi, W. Q.<\/strong>* \u201cDesign, synthesis and biological evaluation of fucose-truncated monosaccharide analogues of ipomoeassin F\u201d, Bioorg. Med. Chem. Lett.<\/em> 2017<\/strong>, 27<\/em>, 2752\u20132756. (\u2020 <\/sup>Equal contribution) (open access<\/a>)<\/p>\n

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3.\u00a0\u00a0\u00a0\u00a0\u00a0 Zong, G.; Whisenhunt, L.; Hu, Z.; Shi, W. Q.<\/strong>*<\/strong> \u201cSynergistic contribution of tiglate and cinnamate to cytotoxicity of ipomoeassin F\u201d, J. Org. Chem.<\/em>\u00a02017<\/strong>,\u00a082<\/em>, 4977\u22124985. (open access<\/a>)<\/p>\n

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2.\u00a0\u00a0\u00a0\u00a0\u00a0 Zong, G.; Aljewari, H.; Hu, Z.; Shi, W. Q.<\/strong>* \u201cRevealing the pharmacophore of ipomoeassin F through molecular editing\u201d, Org. Lett.<\/em>\u00a02016<\/strong>,\u00a018<\/em>, 1674\u22121677. (open access<\/a>)<\/p>\n

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1.\u00a0\u00a0\u00a0\u00a0\u00a0 Zong, G.; Barber, E.; Aljewari, H.; Zhou, J.; Hu, Z.; Du, Y.;\u00a0Shi, W. Q.<\/strong>* \u201cTotal synthesis and biological evaluation of ipomoeassin F and its unnatural 11R<\/em>-epimer\u201d J. Org. Chem.<\/em>\u00a02015<\/strong>,\u00a080<\/em>, 9279\u22129291. (open access<\/a>)<\/p>\n

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Graduate and Postdoctoral Work:<\/span><\/h2>\n

20.\u00a0\u00a0\u00a0 Li, Y., Pasunooti, K., Peng, H.; Li, R.-J., Shi, W. Q.<\/strong>, Liu, W., Cheng, Z.; Head, S., Liu, J.* \u201cDesign and Synthesis of Tetrazole- and Pyridine-Containing Itraconazole Analogs as Potent Angiogenesis Inhibitors\u201d, ACS Med. Chem. Lett.<\/em> 2020<\/strong>, 6<\/em>, 1111\u20131117.<\/p>\n

19.\u00a0\u00a0\u00a0 Li, Y., Pasunooti, K., Li, R.-J., Liu, W., Head, S., Shi, W.<\/strong>, Liu, J.* \u201cNovel Tetrazole-containing Analogs of Itraconazole as Potent Anti-angiogenic Agents with Reduced CYP3A4 Inhibition\u201d, J. Med. Chem.<\/em> 2018<\/strong>, 61<\/em>, 11158\u201311168.<\/p>\n

18.\u00a0\u00a0\u00a0 Bauer, L.,\u00a0Ferla, S.,\u00a0Head, S. A.,\u00a0Bhat, S.,\u00a0Pasunooti, K. K.,\u00a0Shi, W. Q.<\/strong>,\u00a0Albulescu, L.,\u00a0Liu, J. O.,\u00a0Brancale, A.,\u00a0van Kuppeveld, F. J.M.,\u00a0Strating, J. R.P.M.* \u201cStructure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP)\u201d, Antiviral<\/em> Res.<\/em> 2018<\/strong>, 156<\/em>, 55\u201363.<\/p>\n

17.\u00a0\u00a0\u00a0 Head, S.; Shi, W. Q.<\/strong>; Yang, E. J.; Nacev, B. A.; Hong, S. Y.; Pasunooti, K.; Li, R. J.; Shim, J. S.; Liu, J. O.* \u201cSimultaneous targeting of NPC1 and VDAC1 by itraconazole leads to synergistic inhibition of mTOR signaling and angiogenesis\u201d, ACS Chem. Biol.<\/em> 2017<\/strong>, 22<\/em>, 174\u2013182. (open access<\/a>)<\/p>\n

16.\u00a0\u00a0\u00a0 Shim, J. S.; Li, R.; Bumpus, N. N.; Head, S. A.; Kumar, K.; Shi, W.<\/strong>; Liu, J. O.* \u201cDivergence of anti-angiogenic activity and hepatotoxicity of different stereoisomers of itraconazole\u201d, Clin. Cancer Res<\/em>. 2016<\/strong>, 22<\/em>, 2709\u20132720.<\/p>\n

15.\u00a0\u00a0\u00a0 Head, S.; Shi, W.<\/strong>; Zhao, L.; Gorshkov, K.; Pasunooti, K.; Chen, Y.; Deng, Z,; Li, R.; Shim, J. S.; Tan, W.; Hartung, T.; Zhang, J.; Zhao, Y.; Colombini, M.; Liu, J. O.* \u201cThe antifungal drug itraconazole targets VDAC1 to modulate the AMPK\/mTOR signaling axis in endothelial cells\u201d, Proc. Natl. Acad. Sci. U.S.A.<\/em> 2015<\/strong>, 112<\/em>, E7276\u20137285. (open access<\/a>)<\/p>\n

14.\u00a0\u00a0\u00a0 Peng, C.-C.; Shi, W.<\/strong>; Lutz, J. D.; Kunze, K. L.; Liu, J. O.; Nelson, W. L.; Isoherranen, N.* \u201cStereospecific metabolism of itraconazole by CYP3A4: a new metabolic pathway of dioxolane ring scission for azole antifungals\u201d Drug. Metab. Dispos.<\/em> 2012<\/strong>, 40<\/em>, 426\u2013435.<\/p>\n

13.\u00a0\u00a0\u00a0 Shi, W.<\/strong>; Nacev, B. A.; Aftab, B.; Head, S.; Rudin, C. M.; Liu, J. O.* \u201cItraconazole side chain analogs: structure\u2013\u00ad\u00adactivity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and Hedgehog signaling\u201d J. Med. Chem.<\/em> 2011<\/strong>, 54<\/em>, 7363\u20137374. (open access<\/a>)<\/p>\n

12.\u00a0\u00a0\u00a0 Shi, W.<\/strong>; Lowary, T. L.* \u201cEffect of carbohydrate amino group modifications on the cytotoxicity of glycosylated 2-phenyl-benzo[b<\/em>]thiophenes and 2-phenyl-benzo[b<\/em>]furans\u201d Bioorg. Med. Chem. Lett.<\/em> 2011<\/strong>, 21<\/em>, 2591\u20132596.<\/p>\n

11.\u00a0\u00a0\u00a0 Shi, W.<\/strong>; Lowary, T. L.* \u201cStructure\u2013activity relationships in glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b<\/em>]thiophenes and 2-phenyl-benzo[b<\/em>]furans as DNA binding and potential anti-tumor agents\u201d Bioorg. Med. Chem.<\/em> 2011<\/strong>, 19<\/em>, 1779\u20131789.<\/p>\n

10.\u00a0\u00a0\u00a0 Shi, W.<\/strong>; Marcus, S. L.; Lowary, T. L.* \u201cCytotoxicity and topoisomerase I\/II inhibition of glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b<\/em>]thiophenes and 2-phenyl-benzo[b<\/em>]furans\u201d Bioorg. Med. Chem.<\/em> 2011<\/strong>, 19<\/em>, 603\u2013612.<\/p>\n

9.\u00a0\u00a0\u00a0 \u00a0 Shi, W.<\/strong>; Nacev, B. A.; Bhat, S.; Liu, J. O.* \u201cImpact of absolute stereochemistry on the antiangiogenic and antifungal activities of itraconazole\u201d ACS Med. Chem. Lett.<\/em> 2010<\/strong>, 1<\/em>, 155\u2013159. (open access<\/a>)<\/p>\n

8.\u00a0\u00a0\u00a0\u00a0\u00a0 Yang, G.; Tran, H.; Fan, E.; Shi, W.<\/strong>; Lowary, T. L.; Xu, Y.* \u201cDetermination of the absolute configurations of synthetic daunorubicin analogues using vibrational circular dichroism spectroscopy and density functional theory\u201d Chirality<\/em>, 2010<\/strong>, 22<\/em>, 734\u2013743.<\/p>\n

7.\u00a0\u00a0\u00a0\u00a0\u00a0 Shi, W.<\/strong>; Marcus, S. L.; Lowary, T. L.* \u201cSynthesis and antibacterial activity of aminosugar-functionalized intercalating agents\u201d Carbohydr. Res.<\/em> 2010<\/strong>, 345<\/em>, 10\u201322.<\/p>\n

6.\u00a0\u00a0\u00a0\u00a0\u00a0 Shi, W.<\/strong>; Coleman, R. S.; Lowary, T. L.* \u201cSynthesis and DNA-binding affinity studies of glycosylated intercalators designed as functional mimics of the anthracycline antibiotics\u201d Org. Biomol. Chem.<\/em> 2009<\/strong>, 7<\/em>, 3709\u20133722.<\/p>\n

5.\u00a0\u00a0\u00a0\u00a0\u00a0 Fan, E.; Shi, W.<\/strong>; Lowary, T. L.* \u201cSynthesis of daunorubicin analogs containing truncated aromatic cores and unnatural monosaccharide residues\u201d J. Org. Chem.<\/em> 2007<\/strong>, 72<\/em>, 2917\u20132928.<\/p>\n

4.\u00a0\u00a0\u00a0\u00a0\u00a0 Ridgway, K. M.\u00a7<\/sup>; Shi, W.<\/strong>; Lin, S.-J.; Palcic, M. M.; Lowary, T. L.* \u201cChemical and chemoenzymatic synthesis of a trisaccharide fragment of Tsukamurella Paurometabola<\/em> lipoarabinomannan\u201d Can J. Chem.<\/em> 2006<\/strong>, 84<\/em>, 642\u2013649.<\/p>\n

3.\u00a0\u00a0\u00a0\u00a0\u00a0 Luu, T.; Shi, W.<\/strong>; Lowary, T. L.*; Tykwinski, R. R.* \u201cA divergent synthesis of triyne natural products and glycosylated analogues using a carbenoid rearrangement\u201d Synthesis<\/em> 2005<\/strong>, 3167\u20133178.<\/p>\n

2.\u00a0\u00a0\u00a0\u00a0\u00a0 Shi, W.<\/strong>; Qian, X.;* Zhang, R.; Song, G. \u201cSynthesis and quantitative structure\u2013activity relationships of new 2,5-disubstituted-1,3,4-oxadiazoles\u201d J. Agric. Food Chem.<\/em> 2001<\/strong>, 49<\/em>, 124\u2013130.<\/p>\n

1.\u00a0\u00a0\u00a0\u00a0\u00a0 Shi, W.<\/strong>; Qian, X.;* Song, G.; Zhang, R.; Li, R. \u201c<\/strong>Syntheses and insecticidal activities of novel 2-fluorophenyl-5-aryl\/cyclopropyl-1,3,4-oxadiazoles\u201d J. Fluorine Chem.<\/em> 2000, <\/strong>106<\/em>, 173\u2013179.<\/p>\n","protected":false},"excerpt":{"rendered":"

(Corresponding author denoted by *; Undergraduate denoted by \u00a7) Independent: 20. Hall, B. S.; Owusu-Boateng, K.; McPhail, K. L.; Shi, W. Q.; Simmonds, R. E.* \u201cA mycobacterial Sec61 inhibitor disrupts lysosome function by blocking Vacuolar-ATPase biosynthesis\u201d, Eur. J. Cell Biol. 2026, 151541. (open access) 19. Sicairos, B.; Zhou, J.; Hu, Z.; Zhang, Q.;*\u00a0 Shi, W. […]<\/p>\n","protected":false},"author":35,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-page\/page-full-width.php","meta":{"footnotes":""},"class_list":["post-116","page","type-page","status-publish","hentry"],"yoast_head":"\nPublications - Shi Research Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/people.bsu.edu\/wqshi\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications - Shi Research Group\" \/>\n<meta property=\"og:description\" content=\"(Corresponding author denoted by *; Undergraduate denoted by \u00a7) Independent: 20. Hall, B. S.; Owusu-Boateng, K.; McPhail, K. L.; Shi, W. Q.; Simmonds, R. E.* \u201cA mycobacterial Sec61 inhibitor disrupts lysosome function by blocking Vacuolar-ATPase biosynthesis\u201d, Eur. J. Cell Biol. 2026, 151541. (open access) 19. Sicairos, B.; Zhou, J.; Hu, Z.; Zhang, Q.;*\u00a0 Shi, W. 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