Month: November 2020

Ipomoeassin F was discovered to have in vitro activity against SARS-CoV-2 (COVID-19)!

November 25, 2020 by Wei Shi

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Our manuscript was accepted for publication in the Journal of Organic Chemistry!

November 23, 2020 by Wei Shi

Two new ring-size varying analogues of ipomoeassin F were synthesized and evaluated. Improved cytotoxicity (IC50: from 1.8 nM) and in vitro protein translocation inhibition (IC50: 35 nM) derived from ring expansion imply that the binding pocket of Sec61α (isoform 1) can accommodate further structural modifications, likely in the fatty acid portion. Streamlined preparation of a […]

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Congratulations to Ashley for being awarded an Honors Undergraduate Fellowship!

November 13, 2020 by Wei Shi

Congratulations to Ashley Anderson for being awarded an Honors Undergraduate Research Fellowship to support her research in Spring and Fall 2021. The short-term goal of Ashley’s research is to synthesize an amino acid-modified fatty acid fragment that can be used to develop chimeric molecular hybrids derived from ipomoeassin F and cotransin. Biological evaluation of such […]

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Congratulations to Lauren! Her Honors Undergraduate Fellowship got renewed!

November 13, 2020 by Wei Shi

Congratulations to Lauren Andrews for being awarded an Honors Undergraduate Research Fellowship to continue to support her research in Spring and summer 2021. The short-term goal of Lauren’s research is to couple a glucose donor with an arabinose acceptor to make a key disaccharide precursor that can be used to make novel derivatives of ipomoeassin […]

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Congratulations to Lauren for being awarded the Newell C. Cook Sr. & Jr. Scholarship!

November 8, 2020 by Wei Shi

The Newell C. Cook Sr. and Jr. scholarship has been established in the memories of Newell Choice Cook Sr., and Newell Choice Cook Jr., by the generous donations of Kathleen L. Cook, Nancy C. Behforouz, and Mohammad Behforouz. The purpose of the scholarship is to help promote and reward excellence among students studying in the […]

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Shi Research Group

Using Bioactive Small Molecules to Explore Biology

Month: November 2020

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Ipomoeassin F was discovered to have in vitro activity against SARS-CoV-2 (COVID-19)!

Our manuscript was accepted for publication in the Journal of Organic Chemistry!

Congratulations to Ashley for being awarded an Honors Undergraduate Fellowship!

Congratulations to Lauren! Her Honors Undergraduate Fellowship got renewed!

Congratulations to Lauren for being awarded the Newell C. Cook Sr. & Jr. Scholarship!